Varicella, more commonly known as chickenpox, and herpes zoster are known clinical manifestations of infection with varicella-zoster virus (VZV). Chicken pox, the clinical syndrome usually produced as a result of the primary infection with VZV, is a highly contagious disease characterized by widely spread vesicular eruptions and fever. The disease most commonly affects children from five to eight years of age, although adults and younger children, including infants, may develop chickenpox.

Herpes zoster is mainly a disease of adults, with most cases appearing in patients fifty years or older. Fever and painful localized vesicular eruptions of the skin along the distribution of the involved nerves are the most common clinical symptoms of the condition.

The sensitivity, specificity, and reproducibility of enzyme-linked immunoassays is comparable to other serological tests for antibody.